She was born a princess of Lesotho to Prince Masupha Seeiso of Lesotho and late Princess Princess Mabereng Masupha Seeiso. This makes her the first cousin of HM King Letsie III of Lesotho.
Queen Sekhothali Mabhena is a champion and huge of ending child marriages and sexual abuse and reproduction health in which she collaborates with organisations such as the United Nations women.
- Member of the United Nations Women Africa in Ending Child Marriage and FGM (2018 – current).
- Sexual Reproductive Health and Rights (SRHR) advocate (2018 – current).
- Ambassador for Menstrual Hygiene with Sex Rights Network under the AIDS foundation South Africa (2019 – current).
- Steering Committee Member and Youth Representative for the Council of Traditional Leaders of Africa (COTLA) (2019 – current)
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